This study was to investigate the effect of Danchunwhangagam(DCWGG) extract on the production of proinflammatory cytokines in peripheral blood mononuclear cells (PBMCs) from Cerebral infarction(CI) patients.
Methods: We examined how the inhibition rate of tumor necrosis factor (TNF)-alpha, interleukin(IL)-1alpha, IL-1beta, IL-6, and IL-8 productions in DCWGG pretreatment PBMCs culture supernatant in the lipopolysaccaride(LPS)- or desferrioxamine(DFX)treated cells compared to unstimulated cells.
Results: DCWGG inhibited the productions of TNF-alpha, IL-1alpha, IL-1beta, IL-6, and IL-8 induced by LPS in a dose-dependent manner.
Conclusions: DCWGG might have regulatory effects on LPS or DFX-induced cytokine production, which might explain its beneficial effect in the treatment of CI.
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